18 W. Chen, E. C. X. Ang, S. M. Tan, Z. Chua, J. Ren, Z. Yang, B. Teng, R. Lee*, H.-H. Lu*, C.-H. Tan*, "Enantioselective Addition-Alkylation of α,β-Unsaturated Carbonyls via Bisguanidinium Silicate Ion Pair Catalysis", J. Am. Chem. Soc. 2020, 142, 19065-19070.
17 M.-Y. Cao, B.-J. Ma, Z.-Q. Lao, H. Wang, J. Wang, J. Liu, K. Xing, Y.-H. Huang, K.-J. Gan, W. Gao, H. Wang, X. Hong, H.-H. Lu*, "Optically Active Flavaglines-Inspired Molecules by a Palladium-Catalyzed Decarboxylative Dearomative Asymmetric Allylic Alkylation", J. Am. Chem. Soc. 2020, 142, 12039-12045.
- A new class of Trost-type ligands bearing a chiral cycloalkane framwork
- An unprecedented Pd-catalyzed dearomative AAA (> 30 examples, up to 96% ee)
- A new blueprint for flavagline-based drug development by a DOS design
16 M.-Y. Cao, Z.-M. Xu, W. Gao, J. Liu, F. Tan*, H.-H. Lu*, "Catalytic Asymmetric Synthesis of a New Class of CyPHOX Ligands", Tetrahedron 2019, 75, 3282-3291.
- Invited for Ryan Shenvi Award Issue
- Four newly designed CyPHOX ligands with chiral cyclohexane scaffold replacing the previous planar aryl group of PHOX ligands, were efficiently prepared. The synthesis features a kinetically controlled asymmetric phos-Michael reactions of trisubstituted cyclic carboxylates, which is quite simple, reliable and scalable. Preliminary tests with our CyPHOX ligands showed that they exhibited better performance (44-67% ee) than the privileged PHOX ligand (13% ee) in Lam's nickel-catalyzed desymmetrizing arylative cyclization.
15 H.-H. Lu, S. Pronin, Y. Antonova-Koch, S. Meister, E.A. Winzeler, R. A. Shenvi*, “Synthesis of (+)-7,20-Diisocyanoadociane and Liver Stage Antiplas-modial Activity of the ICT Class”, J. Am. Chem. Soc. 2016, 138, 7268-7271.
14 H.-H. Lu, M. Martinez, R. A. Shenvi*, “An Eight-step, Gram-Scale Synthesis of (–)-Jiadifenolide”, Nat. Chem. 2015, 7, 604-607.
- Highlighted in Chemistry World, July 27 2015;
- Highlighted by E. M. Carreira and M. Westph, Synfacts 2015, 11, 089;
- # 1 most read article, June-July 2015.
13 H.-H. Lu, B. Hinkelmann, T. Tautz, J. Li, R. Franke, F. Sasse, M. Kalesse*, “Paleo-Soraphens: Chemical Total Syntheses and Biological Studies”, Org. Biomol. Chem. 2015, 13, 8029-8036.
12 M. Kalesse*, M. Cordes, G. Symkenberg, H.-H. Lu, “The Vinylogous Mukaiyama Aldol Reaction (VMAR) in Natural Product Synthesis”, Nat. Prod. Rep. 2014, 31, 563-594.
11 H.-H. Lu, A. Raja, R. Franke, D. Landsberg, F. Sasse, M. Kalesse*, “Syntheses and Biological Evaluation of Paleo-Soraphens”, Angew. Chem. Int. Ed. 2013, 52, 13549-13552.
10 S.-W. Duan, H.-H. Lu, F.-G. Zhang, J. Xuan, J.-R. Chen, W.-J. Xiao*, “Organocatalytic Conjugate Additions of Acetylacetone to 3-Ylideneoxindoles: A Direct Access to Highly Enantioenriched Oxindole Derivatives”, Synthesis 2011, 1847-1852.
9 H.-H. Lu, F. Tan, W.-J. Xiao*, “Enantioselective Organocatalytic Friedel-Crafts Alkylations”, Curr. Org. Chem. 2011, 15, 4022-4045. (Invited Review)
8 F.-G. Zhang, Q.-Q. Yang, J. Xuan, H.-H. Lu, S.-W. Duan, J.-R. Chen, W.-J. Xiao*, “Enantioselective Conjugate Addition of Oximes to Trisubstituted β-Nitroacrylates: An Organocatalytic Approach to β2,2-Amino Acid Derivatives”, Org. Lett. 2010, 12, 5636–5639.
7 H.-H. Lu, H. Liu, W. Wu, X.-F. Wang, L.-Q. Lu, W.-J. Xiao*, “Catalytic Asymmetric Intramolecular Hydroarylations of ω-Aryloxy- and Arylamino Tethered α,β-Unsaturated Aldehydes”, Chem. Eur. J. 2009, 15, 2742-2746.
6 H.-H. Lu, X.-G. Meng, F.-G. Zhang, S.-W. Duan, W.-J. Xiao*, “Enantioselective Michael Reactions of β,β-Disubstituted Nitroalkenes: A New Approach to β2,2-Amino Acids with Hetero-Quaternary Stereocenters”, Org. Lett. 2009, 11, 3946-3949
- Highlighted by B. List and A. Lee, Synfacts 2009, 1164.
5 H.-H. Lu, X.-F. Wang, C.-J. Yao, J.-M. Zhang, H. Wu, W.-J. Xiao*, “Highly Enantioselective Organocatalytic Michael Addition of Nitroalkanes to 4-oxo-Enoates”, Chem. Commun. 2009, 4251-4253.
4 J.-R. Chen, Y.-Y. Lai, H.-H. Lu, X.-F. Wang, W.-J. Xiao*, “Highly Enantioselective Desymmetrization of meso- and Prochiral Cyclic Ketones via Organocatalytic Michael Reaction”, Tetrahedron 2009, 65, 9238-9243.
3 H.-M. Dong, H.-H. Lu, L.-Q. Lu, C.-B. Chen, W.-J. Xiao*, “Asymmetric Friedel-Crafts Alkylations of Indoles with Ethyl Glyoxylate Catalyzed by (S)-BINOL-Ti (IV) Complex: Direct Access to Enantiomerically Enriched 3-Indolyl-hydroxyacetates”, Adv. Synth. Catal. 2007, 349, 1597-1603.
- Highlighted by M. Lautens and P. Thansandote, Synfacts 2007, 1062.
2 Y.-J. Cao, H.-H. Lu, Y.-Y. Lai, L.-Q. Lu, W.-J. Xiao*, “An Effective Bifunctional Thiourea Catalyst for Highly Enantio- and Diastereoselective Michael Addition of Cyclohexanone to Nitroolefins”, Synthesis 2006, 3795-3800.
1 J.-R. Chen, H.-H. Lu, X.-Y. Li, L. Cheng, J. Wan, W.-J. Xiao*, “Readily Tunable and Bifunctional L-Prolinamide Derivatives: Design and Application in the Direct Enantioselective Aldol Reactions”, Org. Lett. 2005, 7, 4543-4545.
